CureDuchenne Ventures

CureDuchenne Ventures was formed in 2014 after the successful exit from an equity investment in Prosensa (acquired by BioMarin Pharmaceuticals for $680M).

CureDuchenne’s portfolio includes wide-ranging projects aimed at finding treatments for Duchenne. This includes investments in companies pursuing dystrophin-restoring approaches as well as those developing anti-inflammatory and other mechanisms contributing to the disease. We also look for novel technologies and platform approaches aimed at overcoming the limitations of existing therapies in development. Investments from CureDuchenne Ventures have successfully leveraged more than $2.3 billion in follow-on financing from venture capital, biotech, and pharmaceutical companies, and have resulted in several successful exits.

Mission

CureDuchenne Ventures’ impact fund deploys donor dollars to fund Duchenne muscular dystrophy treatments with the singular vision of funding a cure for the entire Duchenne community.

Our robust pipeline of therapies comes from a diverse array of cutting edge technologies used to treat all aspects of Duchenne. CureDuchenne Ventures’ early funding helps Duchenne science attract future investments made by VC firms, biotech companies and pharmaceutical companies.

A successful investment made by CureDuchenne Ventures is a success for the entire Duchenne community. 90% of earnings are re-invested back into Duchenne research to further the goal of a cure.

Investments

CureDuchenne Ventures, LLC is the investment arm of CureDuchenne, a national nonprofit dedicated to curing Duchenne muscular dystrophy, the most common and lethal form of muscular dystrophy.

FOUNDED AND FUNDED

Collaborative Trajectory Analysis Project:
to enhance Duchenne clinical trial design


Exonics Therapeutics:
to develop gene-editing therapies for Duchenne; assisted acquisition by Vertex


Myotherix:
developing therapies to improve muscle function and enhance steroid tolerance

FUNDED

4DMT:
to generate novel viral capsids for use in Duchenne gene therapy


Avidity:
oligonucleotide therapeutics agents for exon skipping to muscle, diaphragm and heart


Baebies:
accelerate newborn screening for Duchenne muscular dystrophy


Bamboo Therapeutics:
acquired UNC vector core, worked to facilitate Pfizer acquisition


Capricor Therapeutics:
to support development of cardiac-targeting cell therapy


Chameleon Biosciences:
EVADER technology shields gene therapy virus from the immune system


Dyne Therapeutics:
Dyne’s FORCE™ platform enhances the delivery of exon skipping therapeutics to skeletal, cardiac and smooth muscle with the potential to improve efficacy and reduce dosing frequency


Edgewise Therapeutics:
to target metabolic processes in Duchenne muscle to make them more resistant to activity-induced damage


Kevin Flannigan at Nationwide Children’s:
to develop U7 gene therapy to treat rare duplication mutations


Myosana Therapeutics

Myosana Therapeutics:
to develop a virus-free gene therapy platform for delivering full-length dystrophin


Prosensa:
a spin-out from Leiden University and assisted subsequent acquisition by BioMarin


PTC Therapeutics:
to encourage development of stop-codon read through drugs


RASRx:
a spin-out from USC seeking to develop novel anti-fibrosis therapy


ReveraGen:
to develop an anti-inflammatory with less side effects than current glucocorticoids


Sarepta:
when on clinical hold, enabling first Duchenne drug approval by FDA


Shape Therapeutics:
to support development of their RNA-fix modified CRIPR system to edit mutations in Duchenne RNAne


TRiNDS:
a neuromuscular focused CRO to accelerate drug development for Duchenne


ZappRx:
specialty prescribing application for patients suffering from Duchenne muscular dystrophy

Strategy

CureDuchenne Ventures supports Duchenne research by using philanthropic donations to encourage development of new Duchenne drugs. Through an impact financing model we can provide both grant funding to academic groups, as well as equity financing to biotech and pharmaceutical companies.

100% of proceeds from equity positions in companies are reinvested to support research into next-generation technologies.

Every dollar donated has the ability to fund multiple projects and have a lasting impact on the treatment of Duchenne. Help us create a self-sustaining fund which will redeploy proceeds from exited positions in companies to fund the next-generation of Duchenne research.

Impact Model

CureDuchenne Ventures’ Impact Model of Funding Research

We find, fund and foster early-stage science using philanthropic dollars. We amplify our funding power by exiting our position in companies and reinvesting those returns into emerging scientific research opportunities.

FIND

FIND the next stage Duchenne research that needs additional financial support to make it out of the lab to commercialization.

FUND

FUND the science with DONOR dollars through grants, loans, or equity financing.

FOSTER

FOSTER development of the technology with:

  • In-house company creation and drug development expertise
  • Introduction to Duchenne research and clinical resources
  • Aligning of strategic partnerships
  • Additional capital investments as needed
  • Achieve proof-of-concept and find pharma partners at the right time

Share This Page

Make an Impact

You can advance the care, treatment and cure for Duchenne muscular dystrophy. Contributions in any amount can truly make a difference and can be credited to a fundraiser or event from the list below.

Donate